2'-Deoxycoformycin

CAS: 53910-25-1

Ref. 3D-AD03945

Product Information

• Name: 2'-Deoxycoformycin
• Synonyms: pentostatin, (8R)-3-(2-Deoxy-β-<span class="text-smallcaps">D</span>-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol, (8R)-3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol, (8R)-3-[(4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-7,8-dihydro-4H-imidazo[4,5-f][1,3]diazepin-8-ol, (R)-3-(2-Deoxy-Beta-D-Erythro-Pento-Furanosyl)-3,6,7,8-Tetrahydroimidazo[4,5-D, (R)-3-(2-Deoxy-Beta-D-Pentofuranosyl)-3,6,7,8-Tetrahydroimidazo(4,5-D)(1,3)D, (R)-Deoxycoformycin, (R)-Rahydro, 2'-Dcf, 2'-Dexoycoformycin, 2’-Deoxycoformycin, 2’Dcf, Ci-825, Cl 67310465, Cl 825, Co-V, Co-Vidarabine, Coforin, Deaminase inhibitor, Deoxycoformycin, Imidazo[4,5-d][1,3]diazepin-8-ol, 3-(2-deoxy-β-<span class="text-smallcaps">D</span>-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (8R)-, Imidazo[4,5-d][1,3]diazepin-8-ol, 3-(2-deoxy-β-<span class="text-smallcaps">D</span>-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (R)-, Imidazo[4,5-d][1,3]diazepin-8-ol, 3-(2-deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (8R)-, Imidazo[4,5-d][1,3]diazepin-8-ol, 3-(2-deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (R)-, Nipent, Nsc 218321, Nsc 247520, Pd-Adi, Vira A deaminase inhibitor
• CAS: 53910-25-1

Description

2'-Deoxycoformycin is a drug that inhibits the synthesis of DNA, RNA, and proteins. It is an analog of coformycin which has been shown to be effective against congestive heart failure. 2'-Deoxycoformycin inhibits the surface glycoprotein on T-cells and also inhibits the proliferation of human T-cell lymphoma cells in culture. This drug has minimal toxicity and can be used to treat infectious diseases. 2'-Deoxycoformycin binds to the mcl-1 protein which regulates apoptosis, hematopoiesis, and inflammation. The drug may inhibit multidrug resistance by binding to a site that is not accessible to pentostatin or other nonsteroidal anti-inflammatory drugs. The drug has been shown to inhibit the growth of bowel disease in animals. 2'-Deoxycoformycin binds reversibly to DNA polymerase alpha or beta at concentrations that are 10 times lower than those needed for inhibition

• Brand: Biosynth

Chemical properties

• Molecular weight: 268.27 g/mol
• Formula: C₁₁H₁₆N₄O₄
• Purity: Min. 95%