Fleroxacin

CAS: 79660-72-3

Ref. 3D-AF23303

Product Information

• Name: Fleroxacin
• Synonyms: Megalone, 3-Quinolinecarboxylic acid, 6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-, 6,8-Difluoro-1-(2-Fluoroethyl)-1,4-Dihydro-7-(4-Methyl-1-Piperazinyl)-4-Oxo-3-Quinolinecarboxylic Acid, 6,8-Difluoro-1-(2-Fluoroethyl)-1,4-Dihydro-7-(4-Methylpiperazino)-4-Oxo-3-Quinolinecarboxylic Acid, 6,8-Difluoro-1-(2-Fluoroethyl)-7-(4-Methylpiperazin-1-Yl)-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid, Am 833, Flerofloxacin, Megalocin, Quinodis, Ro 23-6240, Ro 23-6240/000

Description

Fleroxacin is a fluoroquinolone antibiotic that inhibits the DNA gyrase and topoisomerase IV, which are enzymes that maintain the integrity of bacterial DNA. It binds to bacterial 16S ribosomal RNA and inhibits protein synthesis, leading to cell death by inhibiting the production of proteins vital for cell division. Fleroxacin has been shown to be effective against methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium perfringens, although is not active against acid-fast bacteria such as Mycobacterium tuberculosis or Mycobacterium avium complex. Fleroxacin has shown anti-inflammatory properties, which may be due to its inhibition of prostaglandin synthesis. Fleroxacin can also inhibit the production of cytokines in human polymorphonuclear leukocytes. The drug has been shown to have synergistic effects when used with calcium pantothenate

• Brand: Biosynth

Chemical properties

• Molecular weight: 369.34 g/mol
• Formula: C₁₇H₁₈F₃N₃O₃
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C17H18F3N3O3/c1-21-4-6-22(7-5-21)15-12(19)8-10-14(13(15)20)23(3-2-18)9-11(16(10)24)17(25)26/h8-9H,2-7H2,1H3,(H,25,26)
• InChI key: InChIKey=XBJBPGROQZJDOJ-UHFFFAOYSA-N
• SMILES: CN1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn(CCF)c3c2F)CC1