Remdesivir

CAS: 1809249-37-3

Ref. 3D-AG170167

Product Information

• Name: Remdesivir
• Synonyms: GS 5734(2S)-2-{(2R,3S,4R,5R)-[5-(4-Aminopyrrolo[2,1-f][1,2 ,4]triazin-7-yl)-5- cyano-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]phe noxy-(S)-phosphorylamino}propionic acid 2-ethyl-butyl ester
• Brand: Biosynth
• Description: GS 5734, also known as remdesivir is a nucleoside prodrug with broad spectrum antiviral activity against RNA viruses. As remdesivir / GS 5734 is a prodrug, it requires to be triphosphorylated by cellular kinases in order to compete with ATP for incorporation in newly replicated viral RNA. A major benefit of remdesivir in comparison with other antiviral nucleoside analogs is its resistance to proofreading exonucleases, which occur in coronaviruses. This means remdesivir can overcome the repair mechanism and preserve its antiviral activity. Remdesivir was reported to have a therapeutic as well as prophylactic efficacy in a mouse model infected with SARS-CoV-1.

Chemical properties

• Molecular weight: 602.58 g/mol
• Formula: C₂₇H₃₅N₆O₈P
• Purity: Min. 98 Area-%
• Color/Form: Powder