Leucomycin A3

CAS: 16846-24-5

Ref. 3D-AL24876

Product Information

• Name: Leucomycin A3
• Synonyms: 3-Acetate 4B-(3-methylbutanoate)leucomycin VJosamycinAntibiotic YL 704A3EN 141, (2S,3R,4R,6S)-6-{[(2R,3S,4R,5R,6S)-6-{[(4R,6S,7R,9R,10R,11E,13E,16R)-4-(acetyloxy)-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-6-yl]oxy}-4-(dimethylamino)-5-hydroxy-2-methyltetrahydro-2H-pyran-3-yl]oxy}-4-hydroxy-2,4-dimethyltetrahydro-2H-pyran-3-yl 3-methylbutanoate (non-preferred name), (2S,3S,4R,6S)-6-{[(2R,3S,4R,5R,6S)-6-{[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-4-(acetyloxy)-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-6-yl]oxy}-4-(dimethylamino)-5-hydroxy-2-methyltetrahydro-2H-pyran-3-yl]oxy}-4-hydroxy-2,4-dimethyltetrahydro-2H-pyran-3-yl 3-methylbutanoate (non-preferred name), 6-{[6-{[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-4-(acetyloxy)-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-6-yl]oxy}-4-(dimethylamino)-5-hydroxy-2-methyltetrahydro-2H-pyran-3-yl]oxy}-4-hydroxy-2,4-dimethyltetrahydro-2H-pyran-3-yl 3-methylbutanoate (non-preferred name), Antibiotic YL 704A3, Antibiotic YL 704A₃, En 141, Iosalide, Jomybel, Josacine, Josamicina, Josamina, Josamycin solution, Josamycine, Kitasamycin A3, Kitasamycin A₃, Leucomycin A₃, Leucomycin V, 3-acetate 4^B-(3-methylbutanoate), Leucomycin V, 3-acetate 4B-(3-methylbutanoate), Oxacyclohexadecane, leucomycin V deriv., Turimycin A5, Turimycin A₅, Vilprafen, Wilprafen

Description

Leucomycin A3 is a peptide antibiotic that inhibits the growth of bacteria by binding to the il-2 receptor on polymorphonuclear leucocytes. The drug has been shown to be effective in treating infectious diseases such as bacterial meningitis and pneumonia caused by Gram-positive bacteria, such as Streptococcus pneumoniae. Leucomycin A3 was also shown to bind to the tetracycline resistance gene, preventing transcription of the gene and thus inhibiting protein synthesis. This antibiotic has a matrix effect that may be due to its ability to bind to DNA molecules and form crosslinks with proteins. Leucomycin A3 can be used in wastewater treatment because it binds strongly with organic matter, which causes it to precipitate out of solution.

• Brand: Biosynth

Chemical properties

• Molecular weight: 828 g/mol
• Formula: C₄₂H₆₉NO₁₅
• Purity: Min. 95%
• Color/Form: White Powder