Product Information
IRAK4-IN-4 is a research tool for the study of IRAK4. It is an inhibitor that blocks the activity of IRAK4, which is a protein that plays an important role in the activation of NF-κB and MAP kinase pathways. The peptide has been shown to inhibit LPS-induced TNFα production in human monocytes and neutrophils, as well as IL-1β production in mouse macrophages. It has also been shown to inhibit the activation of NF-κB by inhibiting IKKα/β phosphorylation, which usually leads to inhibition of proteasomal degradation of IκBα. This peptide can be used in pharmacological studies as well as cell biology experiments.
Chemical properties
Technical inquiry about: 3D-AZC27658 IRAK4-IN-4
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