A 83-01

CAS: 909910-43-6

Ref. 3D-BA162484

Product Information

• Name: A 83-01
• Synonyms: 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
• Brand: Biosynth

Description

Potent inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7. Inhibits differentiation of rat induced pluripotent stem cells (riPSCs) and increases clonal expansion efficiency. Helps maintain homogeneity and long-term in vitro self-renewal of human iPSCs.

Chemical properties

• Molecular weight: 421.52 g/mol
• Formula: C₂₅H₁₉N₅S
• Purity: Min. 95%
• Color/Form: Off-White Powder
• InChI: InChI=1S/C25H19N5S/c1-17-8-7-13-23(27-17)24-21(19-14-15-26-22-12-6-5-11-20(19)22)16-30(29-24)25(31)28-18-9-3-2-4-10-18/h2-16H,1H3,(H,28,31)
• InChI key: InChIKey=HIJMSZGHKQPPJS-UHFFFAOYSA-N
• SMILES: Cc1cccc(-c2nn(C(=S)Nc3ccccc3)cc2-c2ccnc3ccccc23)n1