Product Information
- 2-(2-Chloroacetamido)propanoic acid
- 2-[(2-Chloroacetyl)amino]propanoic acid
- Alanine, N-(2-chloroacetyl)-
- Alanine, N-(chloroacetyl)-
- Alanine, N-(chloroacetyl)-, <span class="text-smallcaps">DL</span>-
- Chloroacetyl-DL-alanine
- N-(chloroacetyl)-L-alanine
- N-(chloroacetyl)alanine
- N-Chloroacetyl-<span class="text-smallcaps">DL</span>-alanine
- N-Chloroacetyl-DL-alanine
- See more synonyms
- Alanine, N-(chloroacetyl)-, DL-
N-(2-Chloroacetyl)alanine is a chloroacetic acid derivative that inhibits the enzyme activity of acetylcholinesterase. It has been shown to be more potent than other reversible inhibitors of this enzyme, such as clorgyline and pyridostigmine. N-(2-Chloroacetyl)alanine binds to the active site of acetylcholinesterase, causing denaturation and inactivation of the enzyme by irreversible inhibition. The binding constant for N-(2-chloroacetyl)alanine is 2.5 x 10 M. This irreversible inhibitor also causes a conformational change in the active site of acetylcholinesterase that increases the affinity for chloride ions. The optimum temperature for this reaction is between 25 and 30 degrees Celsius. Zinc ions may also increase the potency of N-(2-chloroacetyl)alanine by increasing its binding affinity to chloride ions at low concentrations
Chemical properties
Technical inquiry about: 3D-BAA19032 N-(2-Chloroacetyl)alanine
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