1-(2-Hydroxy-4-nitrophenyl)ethan-1-one

CAS: 1834-91-9

Ref. 3D-BAA83491

Product Information

• Name: 1-(2-Hydroxy-4-nitrophenyl)ethan-1-one
• Brand: Biosynth
• Description: 1-(2-Hydroxy-4-nitrophenyl)ethan-1-one (KPNE) is a potassium salt of a diketone that has antitubercular activity. KPNE inhibits the growth of Mycobacterium tuberculosis and has been shown to be effective as an antitubercular agent in animals. KPNE also has antiviral properties, inhibiting the RNA polymerase in HIV, which may be due to its ability to inhibit the synthesis of DNA. The mechanism of action for KPNE is thought to be due to its hydrolysis into 4-aminosalicylic acid, which inhibits bacterial protein synthesis by inhibition of the enzyme dihydrofolate reductase.

Chemical properties

• Molecular weight: 181.15 g/mol
• Formula: C₈H₇NO₄
• Purity: Min. 95%