BAY 677

CAS: 2117404-84-7

Ref. 3D-BB163663

Product Information

• Name: BAY 677
• Synonyms: 5-[(4S)-5-Acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]-2-pyridinecarbonitrile
• Brand: Biosynth
• Description: Bay 677 is a potent inhibitor of the human organic anion transporter (hOAT) that is currently being investigated for its effects on acute lung injury. Bay 677 has been shown to have a pharmacokinetic profile that is suitable for oral administration in humans, while methyl sulfone is metabolized through oxidative pathways. Bay 677 also has a high affinity for hOAT and disrupts the transport of organic anions across the cell membrane, which may be responsible for its anti-inflammatory effects.

Chemical properties

• Molecular weight: 400.35 g/mol
• Formula: C₂₀H₁₅F₃N₄O₂
• Purity: Min. 95%