9-Chloro-5,11-dihydro-5-propyl-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

CAS: 4929-23-1

Ref. 3D-BB178547

Product Information

• Name: 9-Chloro-5,11-dihydro-5-propyl-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
• Synonyms: BI-0115
• CAS: 4929-23-1

Description

BI-0115 is a highly selective inhibitor for the lectin-like oxidised low-density lipoproteins (LDL) receptor 1 (LOX-1). In vitro, BI-0115 inhibits internalisation of oxidised LDL (oxLDL) with IC50 of 5.4?µM. The crystal studies revealed that BI-0115 glues two LOX-1 dimers together, resulting in blocked access of oxLDL. LOX-1 is a Ctype lectin-like receptor expressed on endothelial cells, macrophages and vascular smooth muscle. It is responsible for the regulation, internalisation and degradation of oxidised low-density lipoproteins (oxLDL). BI-0115 is a novel inhibitor to LOX-1 and is a valuable tool to study LOX-1 biology, and their role in diseases, such as, cancer and atheroschelerosis.

• Brand: Biosynth

Chemical properties

• Molecular weight: 287.87 g/mol
• Formula: C₁₅H₁₄ClN₃O
• Purity: Min. 98 Area-%
• Color/Form: Yellow Powder
• InChI: InChI=1S/C15H14ClN3O/c1-2-8-19-13-4-3-7-17-14(13)18-12-9-10(16)5-6-11(12)15(19)20/h3-7,9H,2,8H2,1H3,(H,17,18)
• InChI key: InChIKey=QTCZUCSALXBZQR-UHFFFAOYSA-N
• SMILES: CCCN1C(=O)c2ccc(Cl)cc2Nc2ncccc21