Product Information
- 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine HF-1854
- 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-
- 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
- 8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
- Apo-Clozapine
- Asaleptin
- Azaleptin
- Azaleptine
- Brn 0764984
- Ccris 9171
- See more synonyms
- Clorazil
- Cloril
- Clozapex
- Clozapin
- Clozapina
- Clozapina [INN-Spanish]
- Clozapinum
- Clozapinum [INN-Latin]
- Clozaril
- Fazaclo
- Fazaclo ODT
- Hf-1854
- Hsdb 6478
- Iprox
- Klozapol
- Leponex
- Lx 100-129
- Sizopin
- Unii-J60Ar2Ikic
- W-801
Clozapine, a dibenzodiazepine, demonstrates antagonistic activity at the dopamine receptors, further binding to serotonin (5-HT1A, 5-HT2A-C, 5-HT6, 5-HT7), alpha 1 and 2 adrenergic, histamine 1 and M1-M5 muscarinic receptors. In particular, its partial 5-HT1A agonist behaviour, its low affinity for the D2 Dopamine receptors and its antagonistic activity at 5-HT2A receptors, are properties, which make it useful as an antipsychotic drug. The FDA has approved Clozapine for use in the alleviation of symptoms in treatment-resistant schizophrenia patients, such as the risk of self-harm. Although not yet approved by the FDA, Clozapione exerts positive effects in Parkinson’s disease and bipolar disorder treatments. However, Clozapione is not currently a first line-therapy option, as it may cause agranulocytosis and other side effects such as orthostatic hypotension and hypersalivation.
Clozapine is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.
Chemical properties
Technical inquiry about: 3D-BC164328 Clozapine - Bio-X ™
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