Product Information
1-(4-Methoxyphenyl)prop-2-en-1-ol (1MPE) is a model compound that has been shown to inhibit the growth of cancer cells in vitro and in vivo. 1MPE inhibits the activity of human liver enzymes, such as cytochrome P450, which are involved in metabolizing xenobiotics and drugs. 1MPE also binds to the DNA repair enzyme topoisomerase II alpha and inhibits its activity. The binding of 1MPE with this enzyme prevents the relaxation of DNA, leading to cell death by apoptosis. 1MPE has been shown to have toxic effects on rat primary hepatocytes and rat liver microsomes. It also inhibits the growth of CD-1 mice transplanted with human colon tumor cells. In addition, 1MPE is excreted unchanged in urine samples from rats dosed orally with high doses of this drug.
Chemical properties
Technical inquiry about: 3D-BCA41044 1-(4-Methoxyphenyl)prop-2-en-1-ol
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