D-(-)-Amethopterin hydrate

CAS: 51865-79-3

Ref. 3D-BCA86579

Product Information

• Name: D-(-)-Amethopterin hydrate
• Synonyms: (R)-Methotrexate, <span class="text-smallcaps">D</span>-Amethopterin, <span class="text-smallcaps">D</span>-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, <span class="text-smallcaps">D</span>-Methotrexate, D-Amethopterin, D-Methotrexate, D-glutamic acid, N-(4-(((2,4-diamino-6-pteridyl)methyl)methylamino)benzoyl)-, Glutamic acid, N-(p-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-, D-, N-(4-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-D-glutamic acid, N-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)-D-glutamic acid, N-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)glutamic acid, N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-<span class="text-smallcaps">D</span>-glutamic acid, Nsc 117356

Description

D-(-)-Amethopterin hydrate is an analog of methotrexate, a chemotherapy drug used to treat cancer. It is a potent inhibitor of dihydrofolate reductase, an enzyme involved in the synthesis of DNA, RNA and proteins. D-(-)-Amethopterin hydrate has been shown to induce apoptosis in cancer cells by inhibiting the activity of kinases that regulate cell growth and survival. This drug has also demonstrated anti-tumor activity in human cancer cell lines and Chinese hamster ovary cells. Additionally, D-(-)-Amethopterin hydrate has been found to enhance the activity of rifampicin, an antibiotic used to treat tuberculosis. Its potential as a therapeutic agent for cancer treatment makes it a promising candidate for further research and development.

• Brand: Biosynth

Chemical properties

• Molecular weight: 454.4 g/mol
• Formula: C₂₀H₂₂N₈O₅
• Purity: Min. 95%