Product Information
- E 52862
- MR-309
- 4-[2-[[5-Methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]morpholine
- S1RA
- Morpholine, 4-[2-[[5-methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]-
E 52862 (S1RA) is a monoclonal antibody that targets the α2δ subunit of voltage-gated calcium channels. It blocks the binding of ATP and reduces neuronal excitability, providing antinociception without causing dependence or addiction. E 52862 has been shown to be an effective treatment for diabetic neuropathy in vivo models. The drug has also been shown to have a sub-effective dose, which may reduce its side effects. E 52862's receptor activity may be due to its ability to inhibit glutamate release and cyclin D2 expression, which are both involved in pain transmission.
Chemical properties
Technical inquiry about: 3D-BE177449 E 52862 (S1RA)
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