Product Information
Name:GNE 140
Brand:Biosynth
Description:Inhibitor of lactate dehydrogenase A (LDHA), which catalyzes the conversion of pyruvate to lactate yielding NAD. The compound binds to the enzymes active site adjacent to NADH with IC50 = 3 nM. LDHA is expressed in many glycolysis-dependent tumors and its inhibition affects global cell metabolism and proliferation.
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Chemical properties
Molecular weight:499.05 g/mol
Formula:C25H23ClN2O3S2
Purity:Min. 95%
InChI:InChI=1S/C25H23ClN2O3S2/c26-20-3-1-2-4-22(20)33-23-21(29)15-25(27-24(23)30,18-9-14-32-16-18)17-5-7-19(8-6-17)28-10-12-31-13-11-28/h1-9,14,16,23H,10-13,15H2,(H,27,30)
InChI key:InChIKey=GLDDJXYFHWRGPI-UHFFFAOYSA-N
SMILES:O=C1CC(c2ccc(N3CCOCC3)cc2)(c2ccsc2)NC(=O)C1Sc1ccccc1Cl
Technical inquiry about: GNE 140
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