RO-9187
CAS: 876708-03-1
Ref. 3D-BKB70803
| 1mg | 338.00 € | ||
| 5mg | 486.00 € | ||
| 10mg | 692.00 € | ||
| 25mg | 1,163.00 € | ||
| 50mg | 1,861.00 € |
Product Information
- 2(1H)-Pyrimidinone, 4-amino-1-(4-C-azido-β-D-arabinofuranosyl)-
- RO 9187
- 4-Amino-1-(4-C-azido-β-D-arabinofuranosyl)-2(1H)-pyrimidinone
- 2′-Deoxy-2′-beta-hydroxy-4′-azidocytidine
RO-9187 is a modified oligonucleotide that inhibits the replication and spread of hepatitis B virus. It is a nucleoside analog with a deoxycytidine kinase-inhibiting activity. RO-9187 has shown antiviral activity in vitro and in vivo against the cell culture-grown hepatitis B virus, as well as against other viruses such as HIV and herpes simplex virus. The drug is pegylated to increase its plasma half-life and reduce renal clearance, making it more suitable for chronic use. RO-9187 has been shown to be active against viral strains that are resistant to other nucleosides analogs, including lamivudine, adefovir dipivoxil, entecavir, and telbivudine.
Chemical properties
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