Product Information
PIK-108 is a peptide used as a research tool to study protein interactions, receptor function, and ligand binding. It interacts with ion channels and inhibits protein interactions. PIK-108 is a potent inhibitor of the human peptidyl prolyl cis/trans isomerase (PPIase) family, which includes PPIases from bacteria, plants, and humans. This inhibition prevents the enzymatic conversion of proline residues in proteins to their cis or trans forms. As a result, PIK-108 can be used to determine the importance of this enzyme for various cellular functions by testing the effect on cell growth.
PIC-108 has been shown to inhibit various members of the human PPIase family at low micromolar concentrations. The IC50 values for several bacterial enzymes are significantly higher than those for mammalian enzymes. The potency of PIK-108 against bacterial enzymes may be due to its high lipophilicity and increased ability to penetrate hydroph
Chemical properties
Technical inquiry about: 3D-BLB39868 PIK-108
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