Product Information
- 2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(2,4-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, sodium salt
- 2H-Pyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(2,4-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, sodium salt (1:1), (4R,12aS)-
- Gsk 1349572A
Dolutegravir is an antiviral agent that blocks the HIV reverse transcriptase enzyme, which is necessary for viral replication. It is a sodium salt that has been shown to be active against a number of other viruses in vitro, including herpes simplex virus type 1 and 2 (HSV-1 and HSV-2), human cytomegalovirus (HCMV), varicella zoster virus (VZV), and hepatitis B virus. Dolutegravir inhibits the growth of bacteria by binding to the 50S ribosomal subunit. It binds with high affinity to human serum proteins and as a result may have long-term toxicity effects on the liver. The drug also has potential for drug interactions with other drugs that are substrates or inhibitors of CYP3A4/5 enzymes.
Chemical properties
Technical inquiry about: 3D-BSB37519 Dolutegravir sodium
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