OICR-0547

CAS: 1801873-49-3

Ref. 3D-BXC87349

Product Information

• Name: OICR-0547
• Brand: Biosynth
• Description: OICR-0547 is a small molecule that was identified by the OICR consortium as a potential antibiotic. It has been shown to have broad-spectrum activity against Gram-positive and Gram-negative bacteria, including drug-resistant strains. OICR-0547 binds to the bacterial ribosome and inhibits protein synthesis, which leads to cell death. The compound also has an inhibitory effect on the growth of several yeast species and mammalian cells. The binding of OICR-0547 to the ribosome induces a change in conformation that prevents peptidyl transferase from synthesizing proteins. This inhibition of translation leads to cell death because it prevents production of proteins vital for cell division. In addition, OICR-0547 inhibits the growth of methicillin resistant Staphylococcus aureus (MRSA), Enterococcus faecalis, Enterobacter cloacae, Pseudomonas aeruginosa, Burkholderia

Chemical properties

• Molecular weight: 542.55 g/mol
• Formula: C₂₈H₂₉F₃N₄O₄
• Purity: Min. 95%