Yellow Fever Virus NS1 Antigen, Recombinant

Ref. 3D-CA6325

Product Information

• Name: Yellow Fever Virus NS1 Antigen, Recombinant
• Brand: Biosynth
• Description: Yellow fever virus NS1 antigen for diagnostic test manufacturers, vaccine developers and researchers globally. This His-tagged, recombinant protein is expressed in HEK293 cells and is derived from strain 17D. Yellow fever virus, a potentially fatal mosquito-borne flavivirus, is prevalent in tropical and subtropical locations in South America and Africa. Yellow fever virus is transmitted to humans mainly by sylvatic mosquito vectors of the genera Haemagogus and Sabethes, but has also been known to be spread by the sinister Aedes aegypti mosquito which is responsible for the current Zika virus epidemic. In humans, the majority of yellow fever infections are asymptomatic; however approximately 15% of infected patients enter what is known as the toxic phase and this can lead to severe complications such as jaundice, multi-organ failure and even death. There is no specific treatment for Yellow fever and, despite access to safe and effective vaccines, the virus is still causing significant health problems in these countries.Laboratory diagnosis is generally accomplished by means of serological testing for the detection of antibodies during the postviremic phase of the disease (i.e. from the 5th day since the onset of symptoms). Yellow fever virus is difficult to diagnose, especially in the early stages, as cross-reaction with other flavivirus infections is common. There are no validated IgM ELISA kits commercially available at present and in order for yellow fever infection to be confirmed by serologically techniques, a differential diagnosis with other flavivirus infections must be carried out.Cymit Quimica's yellow fever virus protein will provide the critical element to further diagnostic companies’ research and development of IgG and potentially IgM assays.