Product Information
- 2-Ketocaproic Acid
- 2-Ketohexanoic acid
- 2-Oxocaproic acid
- Alpha-Ketocaproic Acid
- Hexanoic Acid, 2-Oxo-
- α-Ketocaproic acid
- α-Ketohexanoic acid
- α-Oxo-n-caproic acid
- α-Oxocaproic acid
2-Oxohexanoic acid (2-OHBA) is a fatty acid that is synthesized from the amino acids lysine and methionine. It is involved in mitochondrial metabolism and has been found to be necessary for spermatozoa motility. 2-OHBA has been shown to inhibit the activity of glutamate dehydrogenase, an enzyme that catalyzes the conversion of glutamate to α-ketoglutarate, which is required for energy production. This inhibition leads to a decrease in ATP levels, which may cause a variety of symptoms, including fatigue and weight loss. Furthermore, 2-OHBA inhibits protein synthesis by blocking the incorporation of amino acids into proteins. The inhibition of this process can lead to high ammonia levels in the blood and accumulation of other nitrogenous wastes in tissues such as liver or muscle tissue. Analysis of urine samples has shown that 2-OHBA is excreted unchanged in urine.
Chemical properties
Technical inquiry about: 3D-CAA49275 2-Oxohexanoic acid
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