Product Information
Cyclohexanecarbonyl isothiocyanate (CHITC) is a reactive thiocyanation agent that can be used to modify proteins. CHITC reacts with amines in the presence of an organocatalyst to form a new molecule, N-isothiocyanato-L-cysteine. This reaction produces reactive intermediates that react with other amine groups on the same protein or with other proteins present in solution. This process has been shown to lead to the selective modification of proteins without affecting the biological activity of these proteins.
The reactive intermediates produced by this reaction have been shown to selectively react with primary and secondary amines on proteins, making them unreactive for subsequent reactions with other amines. CHITC does not react with carboxylic acid groups because it lacks a carboxylic acid group. The lack of this functional group also makes CHITC unreactive under conditions where reactive nucle
Chemical properties
Technical inquiry about: 3D-CBA69951 Cyclohexanecarbonyl isothiocyanate
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