Product Information
- 2-Furancarbonyl chloride, tetrahydro-
- Tetrahydro-2-furancarbonyl chloride
- Tetrahydrofuranyl-2-carbonyl chloride
- Tetrahydro-2-furoyl chloride
- 2-Furoyl chloride, tetrahydro-
Tetrahydrofuranyl-2-carbonyl Chloride is a reactive chemical that has been used in the treatment of pediatric cancer. It is a prodrug that undergoes enzymatic hydrolysis to release an active form of hydrochloric acid, which is cytotoxic and induces apoptosis in cells. Tetrahydrofuranyl-2-carbonyl Chloride binds to annexin, which triggers the activation of caspases and leads to the cleavage of poly(ADP-ribose) polymerase (PARP). This cleavage leads to mitochondrial membrane depolarization and subsequent cell death. The x-ray structures of tetrahydrofuranyl-2-carbonyl chloride show that it has an unsymmetrical carbonyl group. When it reacts with chloride ions, it forms an intermediate with a carbonyl group on one side and a bromide ion on the other. This intermediate can then react with
Chemical properties
Technical inquiry about: 3D-CCA44998 Tetrahydrofuranyl-2-carbonyl Chloride
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