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AM 281
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AM 281

CAS: 202463-68-1

Ref. 3D-CIA46368

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Estimated delivery in United States, on Wednesday 15 Jan 2025

Product Information

Name:
AM 281
Synonyms:
  • 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide
  • 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-morpholin-4-ylpyrazole-3-carboxamide
  • 1H-Pyrazole-3-carboxamide, 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-
  • Am 281
Description:

AM281 is a cannabinoid receptor antagonist that binds to the CB1 cannabinoid receptor and blocks the effect of cannabinoids. AM281 has been shown to reduce the number of bowel disease-related symptoms in mice by reversing the up-regulation of toll-like receptors (TLRs) in the colon. AM281 also reduces inflammation and injury by inhibiting DPP-IV, an enzyme that destroys insulin, which leads to a synergistic effect on neurons in rats. AM281 has been shown to have a synergistic effect with DPP-IV inhibitors, leading to an increase in neuronal activity and improved memory retention. It is used for brain injury research, as it blocks the effects of cannabinoids on hippocampal neurons.

Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
Biosynth
Long term storage:
Notes:

Chemical properties

Molecular weight:
557.21 g/mol
Formula:
C21H19Cl2IN4O2
Purity:
Min. 95%
MDL:
Melting point:
Boiling point:
Flash point:
Density:
Concentration:
EINECS:
Merck:
HS code:

Hazard Info

UN Number:
EQ:
Class:
H Statements:
P Statements:
Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

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