AM 281

CAS: 202463-68-1

Ref. 3D-CIA46368

Product Information

• Name: AM 281
• Synonyms: 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide, 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-morpholin-4-ylpyrazole-3-carboxamide, 1H-Pyrazole-3-carboxamide, 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-, Am 281
• CAS: 202463-68-1

Description

AM281 is a cannabinoid receptor antagonist that binds to the CB1 cannabinoid receptor and blocks the effect of cannabinoids. AM281 has been shown to reduce the number of bowel disease-related symptoms in mice by reversing the up-regulation of toll-like receptors (TLRs) in the colon. AM281 also reduces inflammation and injury by inhibiting DPP-IV, an enzyme that destroys insulin, which leads to a synergistic effect on neurons in rats. AM281 has been shown to have a synergistic effect with DPP-IV inhibitors, leading to an increase in neuronal activity and improved memory retention. It is used for brain injury research, as it blocks the effects of cannabinoids on hippocampal neurons.

• Brand: Biosynth

Chemical properties

• Molecular weight: 557.21 g/mol
• Formula: C₂₁H₁₉Cl₂IN₄O₂
• Purity: Min. 95%