Product Information
- MK 0777
- 1,2,4-Triazolo[4,3-b]pyridazine, 7-(1,1-dimethylethyl)-6-[(1-ethyl-1H-1,2,4-triazol-5-yl)methoxy]-3-(2-fluorophenyl)-
- 7-(1,1-Dimethylethyl)-6-[(1-ethyl-1H-1,2,4-triazol-5-yl)methoxy]-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine
TPA 023 is a drug that is used in the treatment of anxiety and depression. It has been found to bind with benzodiazepine binding sites, which are receptors that are located on the surface of neurons. These receptors are activated by benzodiazepines, which can cause sedation and relieve anxiety. TPA 023 binds with high affinity to the α1 subunit of GABA-A receptor, which is responsible for mediating neuronal inhibition. TPA 023 has been shown to inhibit the release of epidermal growth factor (EGF) in cultured cells, suggesting that it may be useful in treating skin conditions such as psoriasis. It also inhibits the activity of lorazepam, a nonselective GABA-A receptor agonist.
Chemical properties
Technical inquiry about: 3D-CKA97751 TPA 023
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