ML 221
CAS: 877636-42-5
Ref. 3D-CKB63642
| 1mg | To inquire | ||
| 2mg | To inquire | ||
| 5mg | To inquire | ||
| 10mg | To inquire | ||
| 25mg | To inquire |
Product Information
ML 221 is a monoclonal antibody that specifically binds to follicular growth factor (FGF). It blocks the interaction between FGF and its receptor, thereby inhibiting follicular growth. The effects of ML 221 in vivo have been demonstrated in wild-type mice. In these mice, ML 221 inhibited the proliferation of granulosa cells, which are cells found in the ovaries responsible for producing estrogen. This effect was also seen in human liver cells and endothelial cells. Additionally, ML 221 has been shown to inhibit mitochondrial membrane potential and endothelial cell proliferation. Finally, ML 221 has been shown to decrease the severity of proliferative diabetic retinopathy (PDR) by blocking FGF receptors on blood vessels that line the retina.
ML 221 is an experimental drug that inhibits follicular growth and can be used to treat PDR.
Chemical properties
Technical inquiry about: 3D-CKB63642 ML 221
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