I-RW
Ref. 3D-CRB1000057
| 1mg | 183.00 € | ||
| 500µg | 134.00 € |
Product Information
- Ac-RWTWRGSGRWTWR-amideAc-Arg-Trp-Thr-Trp-Arg-Gly-Ser-Gly-Arg-Trp-Thr-Trp-Arg-NH2
The peptide IRW, characterised from egg protein, exhibits inhibitory properties against the angiotensin converting enzyme (ACE2) and could be used to prevent cardiovascular disease with further research. Treatment of hypertensive mice with IRW induced endothelium-dependent vasorelaxation and reduced vascular inflammation. The IRW tripeptide acts as anti-hypertensive by upregulating ACE2 activity via the Mas receptor (MasR) and upregulating Akt/eNOS signalling in the aorta. IRW also induces superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activity. These may play a factor in IRW's role as an anti-inflammatory. IRW shows promise as a nutraceutical for inflammatory conditions and a tool for drug development in cardiovascular disease.
Chemical properties
Technical inquiry about: 3D-CRB1000057 I-RW
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