AIP-I

Ref. 3D-CRB1000249

Product Information

• Name: AIP-I
• Synonyms: [LacS(4,9)]H-YSTCDFIMAIP-1Autoinducing peptide 1AIP1Agr D1 thiolactoneYSTCDFIM (Thiolactone 4-8) H-Tyr-Ser-Thr-Cys(1)-Asp-Phe- Ile-Met(1) (Thiolactone 4-8)AIP-1, Autoinducing peptide 1, AIP1, Agr D1 thiolacto neAIP-1Autoinducing peptide 1AIP1Ag

Description

Auto-inducing peptide (AIP) is a cyclic thiolactone quorum sensing peptide from Staphylococcus aureus which is responsible for activating the agr response. AIP is released from the bacteria and its extracellular concentration is then sensed by a two-component system on the bacterial surface, AgrC and AgrA. AgrC is the membrane histidine kinase receptor and AgrA is a response regulator- upon binding of AIP, AgrC phosphorylates AgrA.AIP accumulates during growth activating an AgrC and AgrA cascade when it reaches a critical signal level. This cascade activates P2 and P3 promoters which autoactivate the agr system and upregulate RNAIII transcription. RNAIII regulates the expression of virulence factors including toxins, super-antigens, and exo-enzymes. Extensive research to identify AIP:AgrC inhibitors aims to find therapeutics against pathogens.AgrD is the precursor peptide of AIP, and AgrB is an integral membrane endopeptidase essential to biosynthesize AIP. This AIP system is conserved among many Gram-positive bacteria. S. aureus strains are categorized into four groups (I-IV) according to their AIP signal and cognate extracellular receptor, AgrC. AIP-I has the characteristic five-residue thiolactone ring with a short N-terminal extension. AIP-I has been used to generate a biosensor for the detection of S. aureus in nanomolar range for use in hospital settings.

• Brand: Biosynth

Chemical properties

• Molecular weight: 961.11 g/mol
• Formula: C₄₃H₆₀N₈O₁₃S₂
• Color/Form: Powder