PD-1 (21-35)
Ref. 3D-CRB1000338
| 1mg | 271.00 € | ||
| 500µg | 198.00 € |
Product Information
- H-PGWFLDSPDRPWNPP-NH2CD_antigenCD279PG-W-FLDSPDRP-W-NPP-amideH-Pro-Gly-Trp-Phe-Leu-Asp-Ser-Pro-Asp-Arg-Pro-Trp-Asn-Pro-Pro-NH2C D_antigen: CD279CD_antigen: CD279
PD-1 (21-35) peptide is derived from the programmed cell death-1 (PD-1) which interacts with its ligand, PD-L1 to regulate immune homeostasis. PD-1 and its ligand PD-L1 are critical in regulating T cell activation, tolerance and immuno-pathology. PD-1 is an immune checkpoint and guards against autoimmunity through two mechanisms. First, it promotes apoptosis of antigen-specific T-cells in lymph nodes. Second, it reduces apoptosis in regulatory T cells.Several types of cancer cells overexpress PD-L1 in order to escape from the PD-1/PD-L1 immuno-surveillance mechanism. Consequently PD-1 inhibitors and PD-L1 inhibitors could be used as a therapeutic in the treatment of cancers.
Chemical properties
Technical inquiry about: 3D-CRB1000338 PD-1 (21-35)
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