(Des-octanoyl)-Ghrelin Human

Ref. 3D-CRB1000388

Product Information

• Name: (Des-octanoyl)-Ghrelin Human
• Synonyms: H-GSSFLSPEHQRVQQRKESKKPPAKLQPR-OHDes-Acyl GhrelinDAGDesacyl GhrelinGSSFLSPEHQRVQQRKESKKPPAKLQPR-acidH-Gly-Ser-Ser-Phe-Leu-Ser-P ro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys- Leu-Gln-Pro-Arg-OHDes-Acyl GhrelinDAGDesacyl G
• Brand: Biosynth
• Description: Ghrelin is an orexigenic peptide hormone mainly produced in the stomach as precursor preproghrelin. Cleavage of preproghrelin followed by modification leads to the formation of ghrelin with the addition of a fatty acid to its serine 3 residue- ghrelin is capable of activating the growth hormone release receptor (GHSR). Ghrelin is involved in appetite stimulation and growth hormone release.Most circulating ghrelin is in the non-acylated form (des-octanoyl) ghrelin. (Des-octanoyl)-ghrelin has some distinct functions from ghrelin, the lack of acylation prevents binding to the ghrelin receptor and growth hormone release. However, (des-octanoyl) ghrelin has negative inotropic effects on papillary muscle and cardioprotective function. There is evidence (des-octanoyl) ghrelin inhibits proliferation of certain cancer cell lines, while promoting adipogenesis has been observed in other experiments in vivo.

Chemical properties

• Molecular weight: 3,242.8 g/mol
• Color/Form: Powder