immunoglobulin light chain variable region Light
Ref. 3D-CRB1000524
| 1mg | 198.00 € |
Product Information
- H-WMFGGGTK-OH
Antibodies (or immunoglobulins) are made up of two heavy and two light chains. Each light chain is composed of two tandem immunoglobulin domains: one constant and one variable region domain. In humans, two light chain isoforms exist: kappa and lambda. Only one type of light chain is present in a typical antibody, thus the two light chains of an individual antibody are identical.Individual B-cells in lymphoid tissue possess either kappa or lambda light chains, but never both together. If the lymph node or similar tissue is reactive, or otherwise benign, it should possess a mixture of kappa positive and lambda positive cells. If, however, one type of light chain is significantly more common than the other, the cells are likely all derived from a small clonal population, which may indicate a malignant condition, such as B-cell lymphoma.Ig light chains produced in neoplastic plasma cells, such as in multiple myeloma, are called Bence Jones proteins.
Chemical properties
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