PAR-2 Agonist amide

Ref. 3D-CRB1000569

Product Information

• Name: PAR-2 Agonist amide
• Synonyms: mpa-F(Cha)(Cha)RKPNDK-NH2 mpa is 3-mercaptopropionic acid, Cha is cyclohexyl-L-alanineX-F-[Cha]-[Cha]-RKPNDK-amide3-Mercaptopropi onyl-Phe-[Cha]-[Cha]-Arg-Lys-Pro-Asn-Asp-Lys-NH2, where X-OH is 3-mercaptopropionic ac id, where Cha is cyclohexyl-L-al
• Brand: Biosynth
• Description: Thrombin receptor inhibitory peptide (TRIP). Thrombin activates members of the PAR family of receptors to initiate a variety of signalling pathways.Protease activated receptors (PARs) are a distinctive four-member family of seven transmembrane G protein-coupled receptors (GPCRs) widely expressed in inflammatory cells. PARs are cleaved by certain serine proteases to expose a tethered ligand domain, this ligand domain then binds to and activates the receptors to initiate multiple signalling cascades. This peptide mimics the tethered peptide ligand of PAR- 2, but lacks the S42 residue which is important for receptor activation, and therefore acts as a thrombin antagonist peptide.

Chemical properties

• Molecular weight: 1,297.7 g/mol
• Color/Form: Powder