[Azhx]-ANP (Human)

Ref. 3D-CRB1000609

Product Information

• Name: [Azhx]-ANP (Human)
• Synonyms: [Cyc(7,23)]Azh-SLRRSSCFGGRMDRIGAQSGLGCNSFRY-OHCarperitideAtrial Natriuretic Peptide

Description

ANP (human) is derived from the atrial natriuretic peptide (ANP) which is a cardiac hormone involved in maintaining cardio-renal homeostasis. This occurs through the activation of the guanylyl cyclase-coupled receptor, resulting in the increased concentration of cyclic guanylate monophosphate. Moreover its function in the processes of anti-proliferation and anti-angiogenesis allow it to take part in cardiovascular remodelling.ANP is a member of the natriuretic peptide family and it is encoded by the NPPA gene, located on chromosome 1. Once synthesized from the 151 amino acid pre-prohormone into its biologically active form, ANP is secreted by the atrial cardiomyocytes in the circulating forms: ANP (1-98) and ANP (99-126). This synthesis process involves the signal peptide being removed from the pre-prohormone resulting in pro-ANP (1-126) which is converted into the circulating forms by the type II transmembrane serine protease Corin.At the N-terminus Azhx, 6-azidohexanoic acid, is present.

• Brand: Biosynth

Chemical properties

• Molecular weight: 3,219.5 g/mol