Cyclic L27-11

Ref. 3D-CRB1000753

Product Information

• Name: Cyclic L27-11
• Synonyms: [Bbc]TWLKKRRWKKAK(dP)P
• Brand: Biosynth
• Description: Cyclic L27-11 is a peptidomimetic compound that targets the outer membrane protein LptD. LptD is part of a complex that functions to transport lipopolysaccharides to the cell surface through the C-terminal β-barrel domain lumen, embedded within the outer membrane. Cyclic L27-11 can bind LptD and prevent translocation of lipopolysaccharides across the periplasm, even nanomolar doses were effective. This interaction gives cyclic L27-11 a potent antimicrobial activity particularly against the human pathogen Pseudomonas aeruginosa.Modifications of cyclic L27-11 are under research to improve its stability for drug delivery. The peptide provided here has a D-proline substitution, characterised as have no antimicrobial activity against Pseudomonas aeruginosa.

Chemical properties

• Molecular weight: 1,234.5 g/mol