Ubiquitin K63 Light
Ref. 3D-CRB1000817
| 25nMol | 352.00 € |
Product Information
- H-TLSDYNIQ(K/H-GG)ESTLHLVLR-OHTLSDYNIQ-[K(GG)]-ESTLHLVLR-acidH-Thr-Leu-Ser-Asp-Tyr-Asn-Ile-Gln-[Lys-(Gly-Gly)]-Glu-Ser-Thr-Leu-His -Leu-Val-Leu-Arg-OH
This sequence corresponds to the peptide bond between mammalian Lys63- (K63) linked Ub proteins- where (GG) corresponds to the C-terminus of the side chain appended Ub.K63-linked chains are the second most abundant linkage types found in cells and are modified with Met1-linked chains in mixed or branched architectures. K63-linked chains have a variety of non-degradative roles including: roles in intracellular trafficking- kinase signalling- DNA damage response- inflammatory signalling and NF-KB activation, however they may also be involved in some proteasome dependent pathways.
Chemical properties
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