[5-FAM]-LL-37

Ref. 3D-CRB1000837

Product Information

• Name: [5-FAM]-LL-37
• Synonyms: 5fam-LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES-OH[5-FAM]-LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES-acid[5-FAM]-Leu-Leu-Gly-Asp-Phe-Phe-Arg -Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-A rg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-

Description

LL-37 is a member of the large cationic family of anti-microbial peptides called cathelicidins which have broad-spectrum anti-microbial activity and are expressed in many species. The only cathelicidin found in humans is LL-37, this is produced in epithelial cells, by proteolytic cleavage from the C-terminal of the hCAP-18 protein. LL-37 can be processed into different forms of anti-microbial peptides. As well as its anti-microbial properties LL-37 also regulates many aspects of the innate immune system and overexpression of LL-37 has been linked to autoimmune diseases such as asthma and psoriasis, making LL-37 the most studied form of the human cathelicidin peptides.More recently studies have shown that LL-37 binds to SARS-CoV-2 S protein and inhibits binding to its receptor hACE2, which may inhibit viral entry into the cell. LL-37 is upregulated by vitamin D, therefore this may be one mode of action for the positive outcomes seem with vitamin D treatment for Covid-19.This peptide contains 5-carboxyfluorescein (5-FAM), a widely used green fluorescent tag.

• Brand: Biosynth