[Biotin]-GLP-1

Ref. 3D-CRB1000881

Product Information

• Name: [Biotin]-GLP-1
• Synonyms: Biot-HDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGR-NH2[Biotin]-HDEFERHAEGTFTSDVSSYLEGQAAKEFIA-W-LVKGR-amide[Biotin]-His-Asp-Glu-Phe-Glu-Arg -His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-S

Description

Glucagon-like peptide (GLP)-1 is a gastrointestinal peptide hormone with multiple roles in relation to metabolism. The primary role of GLP-1 is increasing insulin secretion in the presence of high plasma glucose levels, in addition, GLP-1 also suppresses glucagon secretion from the pancreas. GLP-1 slows down gastric emptying and regulates appetite, both valuable in reducing food intake and body weight. These roles of GLP-1 make it a useful target in the management of type 2 diabetes mellitus (T2DM).GLP-1 exerts its effects by binding to and activating the class B G protein-coupled receptor (GPCR): GLP-1 receptor (GLP-1R). Receptor activation in turn activates signalling pathways which culminates in insulin secretion via CAMP and Ca2+ signalling.Recently evidence has increased for GLP-1 playing a cardio-protective role as well as regulating immune responses and even in kidney function. GLP-1 may also exert neuroprotective and neurotropic effects as it can decrease endogenous levels of amyloid-β (Aβ) and prevent Aβ-induced cell death.This peptide contains an N-terminal Biotin tag for simple detection and purification.

• Brand: Biosynth

Chemical properties

• Molecular weight: 4,335.1 g/mol
• Color/Form: Powder