Tregitope 289

Ref. 3D-CRB1000952

Product Information

• Name: Tregitope 289
• Synonyms: H-EEQYNSTYRVVSVLTVLHQDW-NH2EEQYNSTYRVVSVLTVLHQDW-amideH-Glu-Glu-Gln-Tyr-Asn-Ser-Thr-Tyr-Arg-Val-Val-Ser-Val-Leu-Thr-Val-Leu-His-Gl n-Asp-Trp-NH2Axltide
• Brand: Biosynth
• Description: T regulatory cell epitopes (Tregitopes) are a set of natural T cell epitopes derived from immunoglobulin G. These peptides are Treg-activating and show some promise in prophylactic and therapeutic studies in type 1 diabetes mellitus: which is associated with effector T cell (Teff) destruction of insulin-producing pancreatic β-islet cells. In non-diabetics, self-reactive T cells are deleted during thymic development, rendered anergic, or converted into natural regulatory T cells (Tregs) that suppress autoimmune responses.Tregitopes are processed and presented by MHC class II molecules. They can suppress effector T cell responses, and up-regulate Treg-associated cytokines and chemokines. Tregitopes help stimulate 'antigen-specific adaptive tolerance induction' (ASATI) to modulate antigen-specific transplant rejection and to reduce immune responses to allergens in vitro and in vivo.

Chemical properties

• Molecular weight: 2,564.3 g/mol