Exendin 3 (9-39) amide
Ref. 3D-CRB1000986
| 1mg | 271.00 € | ||
| 500µg | 198.00 € |
Product Information
- H-DLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2DLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-amideH-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Ph e-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro- Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
Originally identified in Heloderma horridum horridum (Mexican beaded lizard), exendin-3 shares homology with vasoactive intestinal peptide (VIP), secretin, helospectin I and II and helodermin. Exendin-3 increases cellular cAMP levels and amylase release from pig pancreatic cells.Truncated exendin-3 is a potent and selective GLP-1 receptor antagonist. It inhibits cAMP production and insulin release induced by GLP-1, exendin-3, and exendin-4. It also blocks the inhibitory effect of GLP-1 on food intake in rats. Exendin 3 (9-39) amide is being considered for clinical use in obese patients. This is based on the extensive and consistent data demonstrating its effectiveness as a tool to improve fasting and postprandial levels of glucose and glucagon.
Chemical properties
Technical inquiry about: 3D-CRB1000986 Exendin 3 (9-39) amide
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