Orexin A (monkey)

Ref. 3D-CRB1001105

Product Information

• Name: Orexin A (monkey)
• Synonyms: H-ARLLPDCCRQKTCPCRRYELLHRGGNHAGGLLVL-NH2ARLLPDCCRQKTCPCRRYELLHRGGNHAGGLLVL-amideH-Ala-Arg-Leu-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr- Cys-Pro-Cys-Arg-Arg-Tyr-Glu-Leu-Leu-His-A rg-Gly-Gly-Asn-His-Ala-Gly-Gly-Leu-Leu-Val-Leu-NH2hypocretin
• Brand: Biosynth
• Description: Orexin A is one of two closely related peptides- the orexins (also known as hypocretins). These small neuropeptides are secreted from orexin-containing neurons, located mainly in the lateral hypothalamus (LH). Orexins function via the binding and activation of two G-protein-coupled receptors (GPCRs)- orexin receptor type 1 (OX1R) and 2 (OX2R).Orexins play several vital roles in a range of physiological activities, including: circadian rhythm, feeding behaviour, energy balance, glucose metabolism, neuroendocrine functions, stress-adaptive responses and reward and addiction. Orexins have also been linked to the pathological processes of neurological diseases such as: narcolepsy- depression- ischemic stroke- drug addiction and Alzheimer's disease.This Orexin A peptide contains two disulphide bridges, one between cysteine 7 and cysteine 13, and the other between cysteine 8 and 15. Orexin-A appears to be the isoform most important for the feeding response.

Chemical properties

• Molecular weight: 3,813 g/mol