Biotinylated L57
Ref. 3D-CRB1001193
| 1mg | 284.00 € | ||
| 5mg | 728.00 € | ||
| 500µg | 207.00 € |
Product Information
- H-(C/Biot)TWPKHFDKHTFYSILKLGKH-OH[Cys(Biotin)]-TWPKHFDKHTFYSILKLGKH-acid[Cys(Biotin)]-Thr-Trp-Pro-Lys-His-Phe-Asp-Lys-His-Thr-Phe- Tyr-Ser-Ile-Leu-Lys-Leu-Gly-Lys-Hi s-OH
The blood-brain barrier (BBB) is a major obstacle to drug delivery into the central nervous system (CNS), in particular for macromolecules such as peptides and proteins. However, certain macromolecules can reach the CNS via a receptor-mediated transcytosis (RMT) pathway, and low-density lipoprotein receptor-related protein 1 (LRP1) is one of the promising receptors for RMT. Recent studies have shown that biotinylated L57 binds to LRP1 (CL4)-Fc more efficiently than Angiopep-7 (a different LRP1 ligand), which might explain the improved BBB permeability of L57.
Chemical properties
Technical inquiry about: 3D-CRB1001193 Biotinylated L57
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