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nef peptide [Human immunodeficiency virus type 1] (73-82) acetyl/amide
Ref. 3D-CRB1001223
| 1mg | 271.00 € | ||
| 500µg | 198.00 € |
Product Information
- Ac-QVPLRPMTYK-NH2
Nef is an accessory protein highly conserved amongst all primate lentiviruses, it is essential for viral replication in vivo- it is expressed by human immunodeficiency virus (HIV) HIV-1 and HIV-2.-Nef acts as a downregulator of class I human leukocyte antigens (HLA) expression in HIV-infected cells to help circumvent the immune response, such as Cytotoxic T lymphocytes (CTL) activity. An intact-nef-gene is critical for high viral loads, linked to development of acquired immunodeficiency syndrome (AIDS). Certain alleles of HLA have been associated with maintaining a seronegative status such as HLA-A*1101. This nef peptide sequence (73-82) has highly conserved residues, a study crystalised it bound within HLA-A*1101. Further investigation using this peptide sequence, with the attached acetyl group for added stability, could elucidate the nature of resistance to HIV infection and the nef residues.
Chemical properties
Technical inquiry about: 3D-CRB1001223 nef peptide [Human immunodeficiency virus type 1] (73-82) acetyl/amide
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