![nef peptide [Human immunodeficiency virus type 1] (73-82) acetyl/amide](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3D%2Fthumb-webp%2FCRB1001223.webp&w=3840&q=75)
nef peptide [Human immunodeficiency virus type 1] (73-82) acetyl/amide
Ref. 3D-CRB1001223
1mg
254.00€
500µg
186.00€
Product Information
Name:nef peptide [Human immunodeficiency virus type 1] (73-82) acetyl/amide
Synonyms:
- Ac-QVPLRPMTYK-NH2
Brand:Biosynth
Description:Nef is an accessory protein highly conserved amongst all primate lentiviruses, it is essential for viral replication in vivo- it is expressed by human immunodeficiency virus (HIV) HIV-1 and HIV-2.-Nef acts as a downregulator of class I human leukocyte antigens (HLA) expression in HIV-infected cells to help circumvent the immune response, such as Cytotoxic T lymphocytes (CTL) activity. An intact-nef-gene is critical for high viral loads, linked to development of acquired immunodeficiency syndrome (AIDS). Certain alleles of HLA have been associated with maintaining a seronegative status such as HLA-A*1101. This nef peptide sequence (73-82) has highly conserved residues, a study crystalised it bound within HLA-A*1101. Further investigation using this peptide sequence, with the attached acetyl group for added stability, could elucidate the nature of resistance to HIV infection and the nef residues.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:1,272.7 g/mol
Technical inquiry about: nef peptide [Human immunodeficiency virus type 1] (73-82) acetyl/amide
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