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nef protein (75-82) [Human immunodeficiency virus 1]
Ref. 3D-CRB1001224
| 1mg | 271.00 € | ||
| 500µg | 198.00 € |
Product Information
- H-VPLRPMTY-OH
Nef is an accessory protein highly conserved amongst all primate lentiviruses, it is essential for viral replication in vivo- it is expressed by human immunodeficiency virus (HIV) HIV-1 and HIV-2. Nef acts as a downregulator of class I human leukocyte antigens (HLA) expression in HIV-infected cells to help circumvent the immune response, such as cytotoxic T lymphocytes (CTL) activity. An intact nef gene is critical for high viral loads, linked to development of acquired immunodeficiency syndrome (AIDS). Certain alleles of HLA have been associated with maintaining a seronegative status such as HLA-A*1101. This nef peptide sequence (75-82) was crystallised within the class I B allele HLA B*3501 suggesting an importance of key residues required for HLA interaction resulting in a nonstandard conformational binding.
Chemical properties
Technical inquiry about: 3D-CRB1001224 nef protein (75-82) [Human immunodeficiency virus 1]
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