Biotin TAT (48-60)

Ref. 3D-CRB1001239

Product Information

• Name: Biotin TAT (48-60)
• Synonyms: Biot-(Ahx)GRKKRRQRRRPPQ-OHBiotin-Ahx-GRKKRRQRRRPPQ-acidBiotin-Ahx-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Gln-OHCachectin, TNF-alpha, Tumor necrosis factor ligand superfamily member 2
• Brand: Biosynth
• Description: Biotin TAT (48-60) is a cell penetrating cationic peptide derived from the N-terminus of the Tat protein, which is a trans-activator of the transcription protein present in the human immunodeficiency virus (HIV). The 48-60 region of the TAT peptide is an arginine-rich bascic domain which as a whole has three domains that function to aid HIV through transactivation, DNA binding and nuclear transport. As a cell penetrating peptide (CPP) TAT aids in the cellular uptake of molecules and hence serves a valuable purpose in transduction methods. This property has been demonstrated through its ability of allowing toxins such as the neurotoxin Botulinum neurotoxin Type A, produced by the Clostridium botulinum type A bacteria to penetrate the skin barrier non-invasively.This peptide has a covalently bonded N-terminal Biotin tag that can be used for detection and purification and contains an N-terminal aminohexanoic acid spacer (Ahx).

Chemical properties

• Molecular weight: 2,057.2 g/mol