TNF-alpha (1-26), human

Ref. 3D-CRB1001240

Product Information

• Name: TNF-alpha (1-26), human
• Synonyms: H-VRSSSRTPSDKPVAHVVANPQAEGQL-OHCachectin, TNF-alpha, Tumor necrosis factor ligand superfamily member 2VRSSSRTPSDKPVAHVVANPQAEGQL- acidH-Val-Arg-Ser-Ser-Ser-Arg-Thr-Pro-Ser-Asp-Lys-Pro-Val-Ala-His-Val-Val-Ala-Asn-Pro-Gln-Ala-Glu-Gly-Gl n-Leu-OHCachec
• Brand: Biosynth
• Description: Peptide derived from tumour necrosis factor alpha (TNF-α), a cytokine produced by macrophages, T lymphocytes and natural killer cells. It exerts its function through targeting the transmembrane receptors TNF receptor 1 and TNF receptor 2, the latter of which it has a higher affinity for. When binding to TNF receptor 1 TNF-alpha is pro-apoptotic and when binding to TNF receptor 2 it is anti-apoptotic. TNF-α has further roles in inflammation, immunity and cancer.Expression of the TNF-α gene, located on chromosome 6 in humans is regulated by factors such as nuclear factor kappa b (NFKB).Dysregulation of TNF-α and its receptors can contribute to diseases such as rheumatoid arthritis, Crohn disease and diabetes. Anti-TNF-α can be used as a therapeutic agent to target TNF-α during inflammatory diseases.

Chemical properties

• Molecular weight: 2,729.4 g/mol