Nangibotide
Ref. 3D-CRB1001271
| 1mg | 271.00 € | ||
| 5mg | 608.00 € | ||
| 500µg | 198.00 € |
Product Information
- H-LQEEDAGEYGCM-NH2LR12
Nangibotide, also referred as LR12, is an antagonist of triggering receptor expressed on myeloid cells (TREM)-1, and was derived from residues 94 to 105 of TREM-like transcript-1 (TLT-1).TREM-1 plays a crucial role in the onset of sepsis by amplifying the host immune response. TLT-1- and TLT-1-derived peptides therefore exhibit anti-inflammatory properties by dampening TREM-1 signalling. LR12 blocks TREM-1 by binding to the TREM-1 ligand and provides protective effects during sepsis such as inhibiting hyper-responsiveness, organ damage, and death, without causing deleterious effects. The protective effects of modulating TREM-1 signalling are also evident in other models of inflammation such as: pancreatitis- haemorrhagic shock- inflammatory bowel diseases and inflammatory arthritis.
Chemical properties
Technical inquiry about: 3D-CRB1001271 Nangibotide
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