HIV-1 Rev (34-50)
Ref. 3D-CRB1001409
| 1mg | 284.00 € | ||
| 500µg | 207.00 € |
Product Information
- H-TRQARRNRRRRWRERQR-OH
The full Rev is vital in aiding transport of unspliced viral mRNA from the nucleus. Within Rev there are 3 main functional regions - the arginine rich motif (ARM), the oligomerization domain (OD), and nuclear export sequence (NES). The peptide sequence 34-50 aligns to the ARM motif which binds the Rev Response Element (RRE) in RNA to form a complex which ultimately leads to nuclear export. ARM is able to recognise a wide range of RNA sequence to and still bind to form a Rev dimer. The Rev ARM sequence has also been shown to work as a nuclear localisation sequence that can penetrate cells. In research, Rev ARM has been utilised as a cell penetrating peptide (CPP) for its ability to bind RNA due to the arginine residues presenting multiple sides for binding and thus deliver macromolecules into the cell.
Chemical properties
Technical inquiry about: 3D-CRB1001409 HIV-1 Rev (34-50)
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