HIV-1 Rev (34-50)

Ref. 3D-CRB1001409

Product Information

• Name: HIV-1 Rev (34-50)
• Synonyms: H-TRQARRNRRRRWRERQR-OH
• Brand: Biosynth
• Description: The full Rev is vital in aiding transport of unspliced viral mRNA from the nucleus. Within Rev there are 3 main functional regions - the arginine rich motif (ARM), the oligomerization domain (OD), and nuclear export sequence (NES). The peptide sequence 34-50 aligns to the ARM motif which binds the Rev Response Element (RRE) in RNA to form a complex which ultimately leads to nuclear export. ARM is able to recognise a wide range of RNA sequence to and still bind to form a Rev dimer. The Rev ARM sequence has also been shown to work as a nuclear localisation sequence that can penetrate cells. In research, Rev ARM has been utilised as a cell penetrating peptide (CPP) for its ability to bind RNA due to the arginine residues presenting multiple sides for binding and thus deliver macromolecules into the cell.

Chemical properties

• Molecular weight: 2,436.4 g/mol
• Color/Form: Powder