CoV Main Protease (Mpro) Substrate

Ref. 3D-CRB1001501

Product Information

• Name: CoV Main Protease (Mpro) Substrate
• Synonyms: H-AVLQSGFR-OHAVLQSGFR octapeptide
• Brand: Biosynth
• Description: Substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro). The substrate sequence is derived from residues P4-P5' of the SARS-CoV Mpro N-terminal autoprocessing site and was identified by a docking study. This substrate binds to and acts as a competitive inhibitor of SARS-CoV Mpro, (3CLpro).Experiments show that the octapeptide AVLQSGFR is bound to SARS-CoV Mpro through six hydrogen bonds. It is an effective inhibitor of SARS coronavirus with an EC50 of 2.7 x 10-2 mg/L and is able to block replication of the virus. The octapeptide also shows no detectable toxicity in the host cells.