Tregitope 084

Ref. 3D-CRB1001653

Product Information

• Name: Tregitope 084
• Synonyms: H-GTDFTLTISSLQPED-OH
• Brand: Biosynth
• Description: T regulatory cell epitopes (Tregitopes) are a set of natural T cell epitopes derived from immunoglobulin G. These peptides are Treg-activating and show some promise in prophylactic and therapeutic studies in type 1 diabetes mellitus: which is associated with effector T cell (Teff) destruction of insulin-producing pancreatic β-islet cells. In non-diabetics, self-reactive T cells are deleted during thymic development, rendered anergic, or converted into natural regulatory T cells (Tregs) that suppress autoimmune responses.Tregitopes are processed and presented by MHC class II molecules. They can suppress effector T cell responses, and up-regulate Treg-associated cytokines and chemokines. Tregitopes help stimulate 'antigen-specific adaptive tolerance induction' (ASATI) to modulate antigen-specific transplant rejection and to reduce immune responses to allergens in vitro and in vivo. Tregitope 289 is also available in our catalogue.

Chemical properties

• Molecular weight: 1,622.8 g/mol